Hepatocyte Transplantation and Humoral Alloimmunity
نویسندگان
چکیده
منابع مشابه
Humoral Alloimmunity in Transplantation: Relevance of HLA Epitope Antigenicity and Immunogenicity
HLA mismatching is an important risk factor for antibody-mediated rejection and transplant failure. With the realization HLA antibodies recognize epitopes rather than antigens, it has become apparent that donor-recipient compatibility should be assessed at the epitope level. Recent developments have increased our understanding of the structural basis of HLA antigenicity, i.e., the reactivity wi...
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The pioneering Times Although the concept of Transplantation could be traced back as early as Saint Cosmas and Damian most famous miracle, grafting of a leg to replace a patient’s ulcered leg, it is not before the 50’s that it entered reality. Important steps were made before, from sewing vessels to understanding the basis of the major histocompatibility complex (MHC) in mice (Snell, 1986). Thi...
متن کاملUnlinked memory helper responses promote long-lasting humoral alloimmunity.
Essential help for long-lived alloantibody responses is theoretically provided only by CD4 T cells that recognize target alloantigen, processed and presented by the allospecific B cell. We demonstrate that in an alloresponse to multiple MHC disparities, cognate help for class-switched alloantibody may also be provided by CD4 T cells specific for a second "helper" alloantigen. This response was ...
متن کاملHepatocyte Transplantation
Orthotopic liver transplantation is an established treatment for patients with severe acute and end-stage chronic liver disease. The shortage of donor organs continues to be the rate-limiting factor for liver transplantation throughout the world. Hepatocyte transplantation is a promising treatment for several liver diseases and can, also, be used as a ‘bridge’ to liver transplantation in cases ...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2016
ISSN: 1600-6135
DOI: 10.1111/ajt.13662